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KMID : 0665220200330060614
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Korean Journal of Food and Nutrition
2020 Volume.33 No. 6 p.614 ~ p.623
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Improvements in Cognitive and Motor Function by a Nutrient Delivery System Containing Sialic Acid from Edible Bird’s Nest
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Kim Dong-Myong
Jung Ju-Yeong
Lee Hyung-Kon
Kwon Yong-Seong
Baek Jin-Hong
Han In-Suk
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Abstract
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The objective of this study was to produce a nutrient delivery system (NDS) using sialic acid extracted from edible bird’s nest (EBN), which improves brain function in patients with Alzheimer’s disease and Parkinson’s disease, by affinity bead technology (ABT). The inhibitory activity of acetylcholinesterase (AChE) and pyramidal cells in the dentate gyrus of the hippocampus were analyzed to investigate the effect of a sialic acid NDS on Alzheimer’s disease. Also, the effect of a sialic acid NDS on Parkinson’s disease was evaluated by rota-rod test and pole test in an animal model. Among the groups treated with donepezil, EBN, and sialic acid NDS, the AChE activity was the lowest in the sialic acid NDS-treated group. The results of the hippocampus analysis of the rat model confirmed that the sialic acid NDS inhibited amyloid-beta accumulation depending upon the concentration. Also, the sialic acid NDS group showed more improvement in motor deterioration than the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced group in both the rota-rod test and pole test. Therefore, the sialic acid NDS had an effect of protecting not only Alzheimer’s disease by inhibiting AChE and amyloid-beta accumulation, but Parkinson’s disease by preventing neurotoxicity induced by MPTP.
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KEYWORD
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dementia, Alzheimer’s disease, Parkinson’s disease, bird’s nest, N-acetylneuraminic acid
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